Zapotec civilization, a historical indigenous pre-Columbian civilization and archaeological culture of central Mexico
Zapotec languages, a group of closely related indigenous Mesoamerican languages
Zapotec peoples, contemporary indigenous peoples of Mexico
Zapotecan languages, a group of related Oto-Manguean languages (including Zapotec languages), of central Mesoamerica
Zapotec language (Jalisco), an extinct language from Jalisco state in Mexico, unrelated (despite its name) to the group of Zapotec languages.
